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Interaction between furosemide and the converting enzyme inhibitor benazepril in healthy volunteers.

De Lepeleire, I and Van Hecken, A and Verbesselt, R and Kaiser, Guenther and Barner, A and Holmes, I and De Schepper, P J (1988) Interaction between furosemide and the converting enzyme inhibitor benazepril in healthy volunteers. European journal of clinical pharmacology, 34 (5). pp. 465-468. ISSN 0031-6970

Abstract

Single oral doses of 10 mg converting enzyme inhibitor benazepril (CGS 14824A) and 40 mg furosemide were administered to 12 healthy male volunteers either separately or concomitantly. The pharmacokinetic parameters of benazepril were not influenced by coadministration of furosemide. Urinary excretion of total furosemide was significantly reduced by 10 to 20% in the presence of benazepril. This effect was considered clinically insignificant. Erect blood pressure decreased and pulse rate increased only during concomitant treatment.

Item Type: Article
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Date Deposited: 28 Jan 2012 00:45
Last Modified: 01 Feb 2013 00:45
URI: https://oak.novartis.com/id/eprint/6624

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