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Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.

Bowen, David G and Shoukry, Naglaa H and Grakoui, Arash and Fuller, Michael J and Cawthon, Andrew G and Dong, Christine and Hasselschwert, Dana L and Brasky, Kathleen M and Freeman, Gordon J and Seth, Nilufer P and Wucherpfennig, Kai W and Houghton, Mortimer and Walker, Christopher M (2008) Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of virology, 82 (10). pp. 5109-5114. ISSN 1098-5514

Abstract

The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:17
Last Modified: 13 Oct 2015 13:17
URI: https://oak.novartis.com/id/eprint/65

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