Bowen, David G, Shoukry, Naglaa H, Grakoui, Arash, Fuller, Michael J, Cawthon, Andrew G, Dong, Christine, Hasselschwert, Dana L, Brasky, Kathleen M, Freeman, Gordon J, Seth, Nilufer P, Wucherpfennig, Kai W, Houghton, Mortimer and Walker, Christopher M (2008) Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of virology, 82 (10). pp. 5109-5114. ISSN 1098-5514

Abstract

The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.

Item Type:	Article
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Date Deposited:	13 Oct 2015 13:17
Last Modified:	13 Oct 2015 13:17
URI:	https://oak.novartis.com/id/eprint/65