Asymmetric synthesis of (-)-(S,S)-homaline
Tools
Stonehouse, Jeff, Lee, James, Roberts, Paul, Thomson, James and Davies, Stephen (2012) Asymmetric synthesis of (-)-(S,S)-homaline. Tetrahedron letters, 53 (9). pp. 1119-1121. ISSN 0040-4039
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Abstract
The asymmetric synthesis of (–)-(S,S)-homaline was achieved in 8 steps and 18% overall yield from commercially available starting materials, using the diastereoselective conjugate addition of lithium (R)-N-(3-chloropropyl)-N-(α-methyl-p-methoxybenzyl)amide to methyl cinnamate as the key step.
Item Type: | Article |
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Additional Information: | Generated as part of the EPSRC-CASE collaboration between Novartis and the University of Oxford |
Date Deposited: | 13 Oct 2015 13:14 |
Last Modified: | 13 Oct 2015 13:14 |
URI: | https://oak.novartis.com/id/eprint/6410 |