Jacoby, Edgar, Schuffenhauer, Ansgar, Popov, Maxim, Azzaoui, Kamal, Havill, Benjamin, Schopfer, Ulrich, Engeloch, Caroline, Stanek, Jaroslav, Acklin, Pierre, Rigollier, Pascal, Stoll, Friederike, Koch, Guido, Meier, Peter, Orain, David, Giger, Rudolf K. A., Hinrichs, Juergen, Malagu, Karine, Zimmermann, Juerg and Roth, Hans-Joerg (2005) Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection. Current Topics in Medicinal Chemistry, 5 (4). pp. 397-411. ISSN 1568-0266

Abstract

The NIBR (Novartis Institutes for BioMedical Research) compound collection enrichment and enhancement project integrates corporate internal combinatorial compound synthesis and external compound acquisition activities in order to build up a comprehensive screening collection for a modern drug discovery organization. The main purpose of the screening collection is to supply the Novartis drug discovery pipeline with hit-to-lead compounds for today's and the future's portfolio of drug discovery programs, and to provide tool compounds for the chemogenomics investigation of novel biological pathways and circuits. As such, it integrates designed focused and diversity-based compound sets from the synthetic and natural paradigms able to cope with druggable and currently deemed undruggable targets and molecular interaction modes. Herein, we will summarize together with new trends published in the literature, scientific challenges faced and key approaches taken at NIBR to match the chemical and biological spaces.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 13:56
Last Modified:	31 Jan 2013 01:11
URI:	https://oak.novartis.com/id/eprint/637