The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis.
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Alten, Rieke and Gram, Hermann and Joosten, Leo A and van den Berg, Wim B and Sieper, Joachim and Wassenberg, Siegfrid and Burmester, Gerd and van Riel, Piet and Diaz-Lorente, Maria and Bruin, Gerardus and Woodworth, Thasia G. and Rordorf, Christiane and Batard, Yannick and Wright, Andrew and Jung, Thomas (2008) The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis research & therapy, 10 (3). R67. ISSN 1478-6362
Official URL: http://arthritis-research.com/content/10/3/R67
Abstract
IL-1beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production.
| Item Type: | Article |
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| Date Deposited: | 31 Jan 2012 00:45 |
| Last Modified: | 01 Feb 2013 00:45 |
| URI: | https://oak.novartis.com/id/eprint/6228 |