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Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway.

Stauffer, Frederic and Maira, Sauveur-Michel and Furet, Pascal and Garcia-Echeverria, Carlos (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 1027-1030. ISSN 0960-894X

Abstract

Imidazo[4,5-c]quinoline derivatives have been discovered and developed as potent and effective modulators of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) pathway to lead to clinical development candidates. The SAR data of representative examples of this compound class and their biological profiling in cellular and in vivo settings are presented and discussed.

Item Type: Article
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Additional Information: can archive post-print (ie final draft post-refereeing)
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Date Deposited: 14 Dec 2009 14:07
Last Modified: 31 Jan 2013 01:32
URI: https://oak.novartis.com/id/eprint/6

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