Zhang, Xuanhao, Xu, Lanting, Wu, Bin-3 and Ma, Dawei (2025) Assembly of α-Aryl Sulfones and Allyl Sulfones and Their Amide Analogues via Copper-Catalyzed Coupling Reactions. Organic letters. ISSN 1523-7052

Abstract

A method is described for the synthesis of α-aryl and allylic sulfones and sulfonamides through CuBr/oxalamide-catalyzed coupling at 40 °C. This transformation involves coupling with (hetero)aryl or vinyl bromides and 2-substituted sulfonylacetates (or amide analogues), proceeding via spontaneous hydrolysis and decarboxylation. The conditions are compatible with various functional groups and heterocycles, allowing for the diverse syntheses of the target compounds.

Item Type:	Article
Date Deposited:	23 Dec 2025 00:45
Last Modified:	23 Dec 2025 00:45
URI:	https://oak.novartis.com/id/eprint/59072