Collins, Agnieszka, Meseck, Emily and Hayden, Christopher (2025) Transmission Electron Microscopy of the Peripheral Nervous System: Methods, Sample Preparation, and Case Studies. Toxicologic pathology, online (online). online-online. ISSN 1533-1601

Abstract

Recommendations and practical considerations for sample collection, fixation, preparation and imaging of peripheral nerves and ganglia for resin embedding, light microscopic evaluation and transmission electron microscopy for ultrastructural pathology evaluation, based on the experience of the authors. Uses and limitations of transmission election microscopy in nonclinical safety studies is demonstrated through case studies of control and test article-dosed nonclinical material to highlight common artifacts and findings in this increasingly important tissue for emerging pharmaceutical modalities.

Item Type:	Article
Date Deposited:	02 Dec 2025 00:45
Last Modified:	02 Dec 2025 00:45
URI:	https://oak.novartis.com/id/eprint/58336