Ludwig, Marie-Gabrielle, Bridges, James, Aust, Gabriela, Tall, Greg, Placantonakis, Dimitris, Rosenkilde, Mette, Sabbagh, Laurent, Wiggin, Giselle, Leduc, Richard, Yang, Zhao, van Meir, Erwin, Salinas, Ana Lilias Moreno, Sun, Jinpeng, Ping, Yu Qi and Langenhan, Tobias (2025) Cell-Specific Functions of the BAI/ADGRB Subfamily of Adhesion G-Protein Coupled Receptors. Pharmacological reviews, 15 (6). e70068. ISSN 1521-0081; 0031-6997

Abstract

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and to establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly evident. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in the field and provides a comprehensive assessment of the current understanding of aGPCR biology here. This includes a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches and model systems for their investigation, as well as emerging approaches for their therapeutic targeting.

Item Type:	Article
Keywords:	adhesion GPCRs
Date Deposited:	04 Feb 2026 00:45
Last Modified:	04 Feb 2026 00:45
URI:	https://oak.novartis.com/id/eprint/57111