De Caro, Liberato, Stoll, Thibaud, Grandeury, Arnaud, Gozzo, Fabia and Giannini, Cinzia (2026) Characterization of VitE-TPGS Micelles linked to Poorly Soluble Compounds for Pharmaceutical Applications exploiting the Pair Distribution Function’s Moments. Pharmaceutics, 17 (431).

Abstract

no final abstract yet.
Draft:
We introduce an innovative theoretical framework tailored for the analysis of Pair Distri�bution Function (PDF) data derived from Small-Angle X-ray Scattering (SAXS) measurements of
core-shell micelles. The new approach involves the exploitation of the first derivative of the PDF and
the derivation of analytical equations to solve the core-shell micelle structure under the hypothesis
of a spheroidal shape. These analytical equations enable us to determine the micelle’s aggregation
number, degree of ellipticity, and contrast in electron density between the core-shell and shell-buffer
regions after having determined the whole micelle size and its shell size from the analysis of the first
derivative of the PDF.

Item Type:	Article
Keywords:	micelles, Pair Distribution Function, Small Angle X-Ray Scatterring
Date Deposited:	03 Jun 2025 00:46
Last Modified:	03 Jun 2025 00:46
URI:	https://oak.novartis.com/id/eprint/56270