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High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.

Faller, Bernard and Wang, Jianling and Zimmerlin, Alfred Gilbert and Bell, Leslie and Hamon, Jacques and Whitebread, Steven and Azzaoui, Kamal and Bojanic, Dejan and Urban, Laszlo (2006) High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis. Expert Opinion on Drug Metabolism & Toxicology, 2 (6). pp. 823-833. ISSN 1742-5255

Abstract

This article reviews the use of a selection of in vitro assays implemented at Novartis and intends to address exposure and safety in early drug discovery. The authors' own experience, based on a large number of 'real' drug discovery compounds, is described to reflect on what has worked, where improvement is needed and how to best use the data for decision making. Possible strategies are discussed, and guidelines are provided on how to organise assays, extract value and contribute knowledge from the data.

Item Type: Article
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Date Deposited: 14 Dec 2009 13:58
Last Modified: 31 Jan 2013 01:13
URI: https://oak.novartis.com/id/eprint/560

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