Strain-release trifluoromethoxylation and pentafluorosulfanoxylation of [1.1.0]bicyclobutanes: expanded access to fluorinated cyclobutane hybrid bioisosteres.
Tools
Tools
Kraemer, Yannick, Stephens, Alexander, Jón, Atiba Buldt, Aurelius, Young, Holder, Lauren and Cody, Ross Pitts (2025) Strain-release trifluoromethoxylation and pentafluorosulfanoxylation of [1.1.0]bicyclobutanes: expanded access to fluorinated cyclobutane hybrid bioisosteres. Chemical communications (Cambridge, England). ISSN 1364-548X
Abstract
Methods for formal bromo-trifluoromethoxylation and bromo-pentafluorosulfanoxylation of [1.1.0]bicyclobutanes using AgOCF3 or AgOSF5 and 1,3-dibromo-5,5-dimethylhydantoin are disclosed. These represent complementary strategies to the syntheses of SF5- and CF3SF4-containing cyclobutanes previously reported from our laboratory, ultimately enabling comparative structural studies and in vitro ADME profiling for various fluorinated cyclobutanes.
| Item Type: | Article |
|---|---|
| Date Deposited: | 25 Feb 2025 00:45 |
| Last Modified: | 25 Feb 2025 00:45 |
| URI: | https://oak.novartis.com/id/eprint/55418 |