Kuroda, Yuki, Iida, Jun, Murata, Kozue, Hori, Yuki, Kobiki, Jumpei, Minatoya, Kenji and Masumoto, Hidetoshi (2025) Transplantation of vascularized cardiac microtissue derived from human iPS cells enhances the impaired electrical conduction capacity in a porcine model of myocardial injury. JTCVS Open. ISSN 26662736

Abstract

The submission is a brief research report format. The content describes the application of vascularized cardiac microtissues in a porcine model of myocardial infarction. Efficient regenerative medicine using human pluripotent stem cell-derived cardiac tissue requires achieving electrical synchronization between the graft and the host heart and improving conduction disturbances in the impaired heart. This study aimed to demonstrate that transplantation of human induced pluripotent stem cell (hiPSC)-derived vascularized cardiac microtissue (VCM) can improve these conduction disturbances using a porcine myocardial injury (MI) model. Furthermore, we investigated whether simultaneous pacing of healthy and post-transplantation lesion areas could improve this conduction disturbance.

Item Type:	Article
Keywords:	Cardiac; regeneration; iPS cells; synchronous; arrhythmia
Date Deposited:	08 Apr 2025 00:45
Last Modified:	08 Apr 2025 00:45
URI:	https://oak.novartis.com/id/eprint/54723