Tian, Yingtao, Lanz, Marian, Hoehn, Pascale, Wang, Xiangshan, Wiss, Jacques, Heuberger, Christoph, Jean-Luc, Schmuck, Jiang, Xigui-1, Wang, Jingen and Ding, Yiping (2025) Application-based calibration method for calorimeter FlexyTSC SEDEX. Journal of Thermal Analysis and Calorimetry.

Abstract

The SYSTAG calorimeter FlexyTSC SEDEX is utilized in Novartis safety laboratories to screen the thermal stability of
reaction mixtures in pharmaceutical synthetic processes. In order to improve the accuracy of SEDEX calorimetric tests,
a customized calibration method was developed specifically for the application scenarios of the calorimeter within our
laboratories. During the check test of the new calibration method, it is no longer to detect the endothermic enthalpies of
the melting process of reference solids, but to detect a known electrical power input through a heating resistor inserted into
the silicone oil within the autoclave (sample cell) under continuous stirring. The check test conditions closely mirror those
of the actual tests performed on chemical reaction mixtures. The new calibration method not only significantly improves
the accuracy of the SEDEX test for detecting exothermic heat but also enhances the efficiency of the calibration process.
It provides a valuable model for optimizing existing calibration schemes or developing new ones for calorimeters in safety
laboratories based on their practical applications. In developing this calibration method, the reaction calorimeter (RC1) was
used to validate the electrical energy output of the heating resistor, while the differential scanning calorimeter (DSC) was
employed for cross-validation after the calibration of SEDEX. This endeavor exemplifies how we can make full use of the
advantages of various calorimetric technologies in a safety laboratory to effectively address specific issues, that is crucial
for a safety laboratory engineer when designing safety experiments appropriately to analyze thermal risks.

Item Type:	Article
Keywords:	Calorimeter  Calibration  Thermal stability  SEDEX
Date Deposited:	05 Apr 2025 00:45
Last Modified:	05 Apr 2025 00:45
URI:	https://oak.novartis.com/id/eprint/54581