Design and synthesis of a library of chemokine antagonists
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Baettig, Urs, Akhlaq, Mohammed, Beer, David, Charlton, Steven, Dunstan, Andrew, Bradley, Michelle, Gedeck, Peter, Owen, Charles, Nicklin, Paul, Rosethorne, Elizabeth and Bhalay, Gurdip (2011) Design and synthesis of a library of chemokine antagonists. Bioorganic & Medicinal Chemistry Letters, 21 (21). pp. 6249-6252. ISSN 0960-894X
Abstract
A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combinations of monomers have resulted in providing novel chemokine antagonists which in some cases display dual chemokine receptor antagonism.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | Chemokine Library Solid-phase Automation |
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| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/5316 |