Gallou, Fabrice (2024) Greener Methodologies in Organic Chemistry: A Pathway Towards Sustainable Future. Green Chemistry, 26. pp. 6289-6317.

Abstract

Implementing green chemistry practices has resulted in improved environmental safety and cost efficiency in various pharmaceutical processes, significantly reducing toxic waste production. In this regard, organic solvents are a prominent component of organic reactions and contribute significantly to hazardous waste generation. In contrast, water is a sustainable alternative that serves as a stable, benign, and environmentally friendly solvent. Micellar catalysis using designer surfactants has significantly enhanced water's effectiveness as a solvent in organic synthesis. These surfactant molecules have a unique architecture that improves water's solubility and acts as an initiator or stabilizer for nanoparticles, resulting in efficient catalysis. Micelles also serve as nanoreactors with a high local concentration of reactants, resulting in unprecedented reaction rates and excellent selectivity. Many sustainable protocols using aqueous micellar chemistry in pharmaceutical synthesis have proven highly effective and are discussed in this review. Furthermore, this review will discuss the incorporation of nanocatalysis with earth-abundant first-row transition metals and the role of surfactants as a nanoparticle catalyst stabilizer. The role of specially designed proline-based surfactant PS-750-M as a ligand or capping agent enabling ligand-free metal nanocatalysis is also highlighted. Finally, the review outlines the present challenges and future directions in green chemistry, emphasizing the need for continued research and innovation to promote sustainable and eco-friendly practices benefitting the pharmaceutical industry.

Item Type:	Article
Date Deposited:	02 Jul 2024 00:46
Last Modified:	02 Jul 2024 00:46
URI:	https://oak.novartis.com/id/eprint/53103