Developing Low Molecular Weight PET and SPECT Imaging Agents
Xue, Lian, Jie, Caitlin, Desrayaud, Sandrine and Auberson, Yves (2024) Developing Low Molecular Weight PET and SPECT Imaging Agents. ChemMedChem : chemistry enabling drug discovery.
Abstract
Imaging agents for positron emission tomography (PET) and single-photon emission computerized tomography (SPECT) have shown their utility in many situations, answering clinical questions related to drug development and medical considerations. The discovery and development of imaging agents follow a well-understood process, with variations related to available starting points and to the envisaged imaging application. This article describes the general development path leading from the expression of an imaging need and project initiation to a clinically usable imaging agent. The definition of the project rationale, the design and optimization of early leads, and the assessment of the imaging potential of an imaging agent candidate are followed by preclinical development activities that differ from those required for therapeutic agents. They lead to radiolabeling with a positron emitter and first-in-human clinical studies that will rapidly evaluate the ability of a new imaging agent to address the questions it was designed to answer.
Item Type: | Article |
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Keywords: | Positron Emission Tomography • Imaging • Biomarkers • Target engagement • Clinical translation |
Date Deposited: | 10 May 2024 00:46 |
Last Modified: | 10 May 2024 00:46 |
URI: | https://oak.novartis.com/id/eprint/52985 |