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Direct microtitre plate radioimmunoassay of savoxepine in unextracted plasma.

Lefevre, Gilbert and Duval, Martine and Botta, L and Godbillon, J (1996) Direct microtitre plate radioimmunoassay of savoxepine in unextracted plasma. Journal of immunoassay, 17 (1). pp. 29-46. ISSN 0197-1522

Abstract

An original solid phase method for direct radioimmunoassay of the antipsychotic savoxepine (CGP 19,486 A) in plasma has been developed which does not require the extraction of the parent drug with organic solvents. The assay showed good reproducibility over the working concentration range 1.9-30.6 nmol/l with intra- and inter-assay coefficients of variation < or = 16%. The procedure, which requires only small volumes of plasma (10 microliters), is simple to handle and well suited for routine analysis. The method allowed to investigate the pharmacokinetics of savoxepine in schizophrenic patients given low oral doses of the drug.

Item Type: Article
Date Deposited: 28 Jan 2012 00:45
Last Modified: 01 Feb 2013 00:46
URI: https://oak.novartis.com/id/eprint/5285

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