Wang, Pengcheng (2024) A description paragraph to call for submission of papers for a special issue. Metabolites.

Abstract

Summary*: Issues related to drug safety remain a major bottleneck in drug discovery and development. Recent technological advancements in metabolomics have enabled researchers to measure a large number of compounds in large sets of samples, as well as in single cells. These new advancements have helped to gain insights into the mechanisms of drug toxicity, translatability to humans, prediction of safety events, mitigation of side effects, and development of safety biomarkers. Metabolomics applied to drug metabolism, drug-endobiotic interactions, and drug-drug (food) interactions offers an ideal opportunity to study toxicological effects of drugs.
This special issue is devoted to metabolomics in drug metabolism, drug-drug (food) interactions, and drug toxicity. The topics that will be covered include studies on the metabolomic analyses of the fate of drugs, host responses to drugs (including new modalities such as peptides, antibody-drug conjugates, protein therapeutics, and oligonucleotide therapeutics), as well as endogenous probes for drug-drug (food) interactions. Additional topics include metabolomic analyses of studying mechanism, prediction, and safety biomarkers of drug toxicity. Other topics with similar focus will also be considered.

Item Type:	Article
Date Deposited:	31 Jan 2024 00:45
Last Modified:	31 Jan 2024 00:45
URI:	https://oak.novartis.com/id/eprint/52601