Luescher, Michael and Gallou, Fabrice (2024) The impact of earth-abundant metals as a replacement for Pd in cross coupling reactions. Green chemistry, 26. pp. 5239-5252.

Abstract

Substitution from one metal catalyst to another is not as straightforward and simply justified by the availability and/or cost of the metals. Extensive life cycle assessment was performed to that the commonly held view that use of earth-abundant metals, and mainly Ni, are replacements for palladium in cross coupling reactions, and Suzuki-Miyaura couplings, in particular an incomplete assessment of the entire picture. This notion unfortunately derives from the standpoint of cost, and to some degree, the relative natural abundance of each metal. However, a more realistic appreciation emerges when far more reaction parameters involved in the chemistry are considered. Such an analysis unequivocally points to the major impact on climate change brought on by use of organic solvents, while the metal itself may play a subordinate role. Clearly, this study reveals that various materials can contribute in various ways to the overall carbon footprint. Hence, a more detailed analysis is required!

Item Type:	Article
Date Deposited:	02 Jul 2024 00:46
Last Modified:	02 Jul 2024 00:46
URI:	https://oak.novartis.com/id/eprint/52557