The ascent of mouse: advances in modelling human depression and anxiety.
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Cryan, John F. and Holmes, Andrew (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nature Reviews: Drug Discovery, 4 (9). pp. 775-790. ISSN 1474-1776
Abstract
Psychiatry has proven to be among the least penetrable clinical disciplines for the development of satisfactory in vivo model systems for evaluating novel treatment approaches. However, mood and anxiety disorders remain poorly understood and inadequately treated. With the explosion in the use of genetically modified mice, enormous research efforts have been focused on developing mouse models of psychiatric disorders. The success of this approach is largely contingent on the usefulness of available behavioural models of depression- and anxiety-related behaviours in mice. Here, we assess the current status of research into developing appropriate tests for assessing such behaviours.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 14 Dec 2009 13:58 |
| Last Modified: | 14 Dec 2009 13:58 |
| URI: | https://oak.novartis.com/id/eprint/514 |