Snajdrova, Radka, Buller, Rebecca, Lutz, Stefan, Moore, Jeffrey, Kazlauskas, Romas and Bornscheuer, Uwe (2023) Surfing the biocatalysis wave to new applications Changed to: From nature to industry: Harnessing enzymes for biocatalysis, as per request of Editor. Science, 382 (6673).

Abstract

Biocatalysis applies enzymes to make valuable products. Today, this green technology is effectively utilized from bench scale to industrial production. The last decade has seen an explosion in the development of experimental and in silico tools to tailor enzymatic properties, the latter relying on the surge of available bioinformatic data and continuously accelerating computational advances. By harnessing (chemo)-enzymatic synthesis routes or intricate enzyme cascades, completely new targets can be synthesized, ranging from DNA and complex pharmaceuticals to starch made in vitro simply from CO2-derived methanol. In addition, intriguing new chemistries have emerged by combining biocatalysis with transition metal-, photo- and electrocatalysis. Against this exciting backdrop, this review highlights recent key developments, identifies current limitations, and provides a future prospect for this rapidly developing research field.

Item Type:	Article
Date Deposited:	18 Jan 2024 00:45
Last Modified:	18 Jan 2024 00:45
URI:	https://oak.novartis.com/id/eprint/51208