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Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial.

Abdulla, Salim and Sagara, Issaka and Borrmann, Steffen and D'Alessandro, Umberto and González, Raquel and Hamel, Mary and Ogutu, Bernhards and Mårtensson, Andreas and Lyimo, John and Maiga, Hamma and Sasi, Philip and Nahum, Alain and Bassat, Quique and Juma, Elizabeth and Otieno, Lucas and Björkman, Anders and Beck, Hans Peter and Andriano, Kim and Cousin, Marc and Lefevre, Gilbert and Ubben, David and Premji, Zulfikarali (2008) Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial. Lancet, 372 (9652). pp. 1819-1827. ISSN 1474-547X

Abstract

Combination treatments, preferably containing an artemisinin derivative, are recommended to improve efficacy and prevent Plasmodium falciparum drug resistance. Our aim was to show non-inferiority of a new dispersible formulation of artemether-lumefantrine to the conventional crushed tablet in the treatment of young children with uncomplicated malaria.

Item Type: Article
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Date Deposited: 28 Jan 2012 00:45
Last Modified: 01 Feb 2013 00:47
URI: https://oak.novartis.com/id/eprint/5095

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