Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.
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Abdulla, Salim, Amuri, Baraka, Kabanywanyi, Abdunoor M, Ubben, David, Reynolds, Christine, Pascoe, Steve, Fitoussi, Serge, Yeh, Ching-Ming, Nuortti, Marja, Sechaud, Romain, Kaiser, Guenther and Lefevre, Gilbert (2010) Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects. Malaria journal, 9. p. 253. ISSN 1475-2875
Abstract
Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L) crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L. During early development of this new formulation, two studies were performed in healthy subjects, one to evaluate the palatability of three flavours of A-L, and a second one to compare the bioavailability of active principles between the dispersible tablet and the tablet (administered crushed and intact).
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF may be used |
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| Date Deposited: | 18 May 2011 23:45 |
| Last Modified: | 01 Feb 2013 00:47 |
| URI: | https://oak.novartis.com/id/eprint/5089 |