Gallou, Fabrice (2023) Palladium-catalyzed micellar cross-couplings : An Outlook. Coordination Chemistry Reviews, 488 (1). p. 215158.

Abstract

In the last decades, cross-coupling approaches have been widely used to generate structural diversity efficiently and quickly. Despite significant attention, palladium has remained the most understood metal to catalyze such cross-couplings. The introduction of sustainability parameters such as atom-economy, process mass intensity (PMI), or E-factor exposed the fundamental inefficiencies associated with the traditional practices in organic synthesis. Critical analysis in the context of these factors identified organic solvents as the major culprit. In this scenario, employing water as a bulk reaction medium for cross-couplings in particular has emerged as an attractive alternative. Fine-tuning the solvation features of water by adding non-ionic surfactant provides an exciting opportunity to practice sustainable organic synthesis. This approach has gained substantial attention in the last ten years and established a basic framework for practicing organic chemistry under aqueous conditions, ultimately reducing the reliance on toxic organic solvents. In this review, recent advances in the field of micellar catalysis applied to palladium mediated cross-couplings will be discussed, along with the future directions and challenges.

Item Type:	Article
Date Deposited:	30 May 2023 00:45
Last Modified:	30 May 2023 00:45
URI:	https://oak.novartis.com/id/eprint/49355