Whitebread, Steven, Hamon, Jacques, Bojanic, Dejan and Urban, Laszlo (2005) Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development. Drug discovery today, 10 (21). pp. 1421-1433. ISSN 1359-6446

Abstract

Broad-scale in vitro pharmacology profiling of new chemical entities during early phases of drug discovery has recently become an essential tool to predict clinical adverse effects. Modern, relatively inexpensive assay technologies and rapidly expanding knowledge about G-protein coupled receptors, nuclear receptors, ion channels and enzymes have made it possible to implement a large number of assays addressing possible clinical liabilities. Together with other in vitro assays focusing on toxicology and bioavailability, they provide a powerful tool to aid drug development. In this article, we review the development of this tool for drug discovery, its appropriate use and predictive value.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/S1359-6446(05)03632-9
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	safety pharmacology; radioligand binding; multi-parallel screening; adverse drug reaction; bioprint; Pharmacology; Drug Discovery
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/S1359-6446(05)03632-9
Date Deposited:	14 Dec 2009 13:59
Last Modified:	31 Jan 2013 01:15
URI:	https://oak.novartis.com/id/eprint/487