Aqueous Micelle-Driven Spontaneously Formed Ligand-Free Pal-ladium(0) Nanoparticles are Efficient Catalyst for Cross-Couplings Enabling Biaryl Ketones
Gallou, Fabrice (2022) Aqueous Micelle-Driven Spontaneously Formed Ligand-Free Pal-ladium(0) Nanoparticles are Efficient Catalyst for Cross-Couplings Enabling Biaryl Ketones. ACS Appl. Mater. Interfaces, 14. p. 50947.
Abstract
A novel strategy has been developed to spontaneously form ligand-free Pd(0) nanoparticles from water- and air-sensitive Pd2dba3 in water. These nanoparticles are thoroughly characterized by IR, NMR, and mass spectrometry, revealing that the metal-micelle binding play a critical role in their stability and activity. HRTEM supported the ultrasmall nature of nanopar-ticles, while XPS analysis confirmed the zero-oxidation state of Pd. The shielding effect of micelle and enhanced stability of nanoparticles enabled fast cross-couplings of water-sensitive triazene adducts of carboxylic acid to form non-symmetrical biaryl ketones. These naturally formed nanoparticles are more efficient than new synthetic nanoparticles formed under a hydrogen atmosphere. The activity of naturally formed nanoparticles is compared with synthetic nanoparticles over 34 sub-strates revealing that naturally formed nanoparticles are much more efficient than synthetic nanoparticles.
Item Type: | Article |
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Date Deposited: | 03 Jan 2023 00:45 |
Last Modified: | 03 Jan 2023 00:45 |
URI: | https://oak.novartis.com/id/eprint/48105 |