O'Donnell, Chris and Bradner, Jay (2022) Bridging the Gap to Translating Genomewide Discoveries into Therapies to Prevent and Treat Atherosclerotic Cardiovascular Disease. Circulation, 146 (12). pp. 930-933. ISSN 0009-7322

Abstract

The authors provide a review article that comments on a peer-reviewed article to be published in the journal Circulation:

"Solomon CU, McVey DG, Andreadi C, Gong P, Turner L, Stanczyk PJ, Khemiri S, Chamberlain JC, Yang W, Webb TR, Nelson CP, Samani NJ, Ye S. Effects of coronary artery disease-associated variants on vascular smooth muscle cells."

Comments include a brief overiview of the field of genomics (genomewide association studies=GWAS) of CAD, summary of the "Solomon et al" study findings, strengths and limitations of the "Solomon et al" study, and opportunities and gaps for drug development for prevention and treatment of CAD.

Item Type:	Article
Keywords:	coronary artery disease, functional genomics, editorials, translational medical research
Date Deposited:	28 Feb 2023 00:45
Last Modified:	28 Feb 2023 00:45
URI:	https://oak.novartis.com/id/eprint/47981