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Inhibition of DNA helicases with DNA-competitive inhibitors.

Dubaele, Sandy and Jahnke, Wolfgang and Schoepfer, Joseph and Fuchs, Jean and Chene, Patrick (2006) Inhibition of DNA helicases with DNA-competitive inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (4). pp. 923-927. ISSN 0960-894X


Helicases form an attractive protein family for drug discovery because they are involved in various human diseases. In this report, we show that it is possible to inhibit both the ATPase and the helicase activities of a DNA helicase with dibenzothiepins that bind at its nucleic acid binding site. These results suggest a drug discovery strategy to inhibit DNA helicases.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Helicase; Inhibitor; ATPase
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Date Deposited: 14 Dec 2009 13:59
Last Modified: 31 Jan 2013 01:16


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