Gallou, Fabrice (2023) "Where chemocatalysis meets biocatalysis ... in water. Nature–ally!". Chemical reviews.

Abstract

Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using both chemocatalysis and biocatalysis, oftentimes in a single reaction vessel. Several creative approaches and solutions that enable such combinations to be realized and applied to synthetic problems are presented herein, reflecting the state-of-the-art in this blossoming field. Coverage has been sectioned into three parts: (1) the initial discussion addresses historical developments that led to this area of research; (2) the second portion describes key developments post initial discoveries that have advanced this area, and (3) the third section presents reports covering the literature from roughly 2018 to the present, highlighting the latest achievements that provide attractive solutions to the main question of compatibility between biocatalysis (used predominantly in aqueous media), and chemocatalysis (that remains mainly performed in organic solvents). The discussion concludes with a brief overview of our follow up “review” in this 2-part series, where the realities of chemoenzymatic catalysis, both today and in the near future, as seen by several company representatives, are offered as insight as to where the field stands, and the prognosis for its future in organic synthesis.

Item Type:	Article
Date Deposited:	14 Jan 2023 00:45
Last Modified:	14 Jan 2023 00:45
URI:	https://oak.novartis.com/id/eprint/47471