Gallou, Fabrice (2202) Ligand-free regioselective hydrogenation of naphthyl-P(V) scaf-folds to access phosphine oxide ligands. Angewandte Chemie. International edition, 62. e20230713. ISSN 1521-3773; 0570-0833; 1433-7851

Abstract

Herein, we described the first semi- and regioselective hydrogenation of P(V)-substituted naphthalenes. This iridium-catalyzed reaction delivers phosphine oxides or phosphonates in almost quantitative yields and with total regioselectivi-ty. This report also exposed a novel pathway toward the preparation of H8-BINAP ligands derivatives. The importance of HFIP solvent is evidenced. Catalyst analysis also demonstrated the involvement of ultrasmall iridium(0) nanoparticles, with potential recycling of the catalyst.

Item Type:	Article
Date Deposited:	02 Jul 2024 00:46
Last Modified:	02 Jul 2024 00:46
URI:	https://oak.novartis.com/id/eprint/47393