Bassand, Celine, Villois, Alessia, Gianola, Lucas, Laue, Grit, Ramazani, Farshad, Riebesehl, Bernd, Sanchez-Felix, Manuel, Ullrich, Thomas, Sedo, Kurt and Duvnjak Romic, Marieta (2022) Smart design of patient centric long-acting products: from preclinical to marketed pipeline trends and opportunities. Expert opinion on drug delivery. ISSN 1744-7593

Abstract

We see a development in the field of long-acting products to serve patients with chronic diseases by providing benefits in adherence, efficacy and safety of the treatment. This review investigates features of long-acting products on the market/pipeline to understand which drug substance (DS) and drug product (DP) characteristics likely enable a successful patient-centric, low-dosing frequency product.This review evaluates marketed/pipeline long-acting products with greater than one week release of small molecules and peptides by oral and injectable route of administration (RoA), with particular focus on patient centricity, adherence impact, health outcomes, market trends, and the match of DS/DP technologies which lead to market success.Emerging trends are expected to change the field of long-acting products in the upcoming years by increasing capability in engineered molecules (low solubility, long half-life, high potency, etc.), directly developing DP as long-acting oral/injectable, increasing the proportion of products for local drug delivery, and a direction towards more subcutaneous, self-administered products. Among long-acting injectable products, nanosuspensions show a superiority in dose per administration and dosing interval, overwhelming the field of infectious diseases with the recently marketed products.

Item Type:	Article
Date Deposited:	16 Aug 2022 00:45
Last Modified:	16 Aug 2022 00:45
URI:	https://oak.novartis.com/id/eprint/47291