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Allylations of Aryl/Heteroaryl Ketones: Neat, Clean, and Green. Applications to Targets in the Pharma- and Nutraceutical Industries

Gallou, Fabrice (2022) Allylations of Aryl/Heteroaryl Ketones: Neat, Clean, and Green. Applications to Targets in the Pharma- and Nutraceutical Industries. Green chemistry, 24. pp. 4909-4914.

Abstract

Aromatic and heteroaromatic ketones bearing an α-methine proton can be deprotonated and mono-allylated in minutes in
the complete absence of an organic solvent to arrive at the corresponding products in high isolated yields. Applications to
synthetic targets including both MK-7 and MK-9, as well as coenzyme Q9 (CoQ9) utilizing this new technology are
documented.

Item Type: Article
Date Deposited: 13 Aug 2022 00:45
Last Modified: 13 Aug 2022 00:46
URI: https://oak.novartis.com/id/eprint/47044

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