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Meeting report of the second European Biotransformation Workshop

Walles, Markus (2022) Meeting report of the second European Biotransformation Workshop. Xenobiotica, 52 (4). pp. 426-431.


Challenges and opportunities in the field of biotransformation were presented and discussed at the 2nd European Biotransformation workshop which was conducted virtually in collaboration with the DMDG November 24/25, 2021. Here we summarise the presentations and discussions from this workshop.
The following topics were covered:
1) Regulatory requirements and biotransformation studies for ADCs and ASOs
2) Solutions for mass spectral data processing of peptides and oligonucleotides
3) Future outsourcing needs in biotransformation for new modalities
4) Established quantitative and qualitative workflows for metabolite identification
5) In vitro and microphysiological systems to study new chemical entities (NCEs) with low metabolic turnover
6) New strategies to frontload the human ADME study and to investigate the impact of human microbiome on drug development
Keywords: Biotransformation of new modalities, ADCs, ASOs, metabolite quantitation and qualification, microphysiological systems, human ADME, microbiome

Item Type: Article
Date Deposited: 10 Sep 2022 00:45
Last Modified: 10 Sep 2022 00:46


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