Gallou, Fabrice (2022) The Catalytic Formation of Atropisomers and New Stereocenters via Asymmetric Suzuki-Miyaura Couplings. ACS catalysis, 12 (9). pp. 4918-4937.

Abstract

Although Suzuki-Miyaura cross-coupling is one of the most convenient and well-developed cross-coupling reactions, its applications to the asymmetric version to deliver highly functionalized atropisomers or non-racemic coupling products have been less explored. Besides some excellent work reported intermittently, the asymmetric Suzuki-Miyaura reaction remains a significant challenge, particularly for preparing highly functionalized heterocyclic atropisomers. A concise but critical knowledge on this topic may further inspire researchers across various subdisciplines to develop innovative and sustainable solutions to tackle this problem. Therefore, this concise review aims to summarize the pioneering work on asymmetric Suzuki-Miyaura cross-couplings and cover the new implementations via homogeneous or heterogeneous catalysis reported during recent years. Most notably, the use of transition-metals other than palladium is also described.

Item Type:	Article
Date Deposited:	19 Jul 2022 00:45
Last Modified:	19 Jul 2022 00:45
URI:	https://oak.novartis.com/id/eprint/46947