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Tackling Challenging Targets with High-Throughput Biophysical Screening at Novartis

Kroemer, Markus and Ostermeier, Daniela (2022) Tackling Challenging Targets with High-Throughput Biophysical Screening at Novartis. Scaling Up Surface Plasmon Resonance-Based Screens to Increase Novel Hit Finding.


This application note describes how Novartis successfully identified novel drug candidates
for challenging protein targets by pioneering high-throughput SPR screening. To accomplish
this, they performed their screens on a Sierra SPR®-32† instrument and analyzed their data
using Genedata Screener®. This enabled them to:
• Scale up biophysical screening and employ a multiplexed assay design for initial hit-finding
campaigns. This endeavor allowed for primary screening against mutant forms of the
protein target, resulting in the discovery of novel chemical scaffolds.
• Rapidly process complete campaigns by automating sensorgram processing and
calculations, while giving scientists full control over result review and ability to adapt the
analysis to their workflows.
• Unify data analysis into a single software platform, increasing efficiency and data

Item Type: Article
Date Deposited: 22 Jun 2022 00:45
Last Modified: 22 Jun 2022 00:45


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