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Water: An Underestimated Solvent for Amide Bond-Forming Reactions

Gallou, Fabrice (2022) Water: An Underestimated Solvent for Amide Bond-Forming Reactions. ACS Sustainable Chemistry & Engineering, 10 (16). pp. 5299-5306.


The construction of the amide/peptide bond is among the most performed transformations in the pharmaceutical and chemical industries. The traditional methodologies frequently rely on the use of large amounts of organic solvents, main-ly N,N-dimethylformamide (DMF), N-methyl pyrrolidone (NMP), and dichloromethane (CH2Cl2). These solvents adverse-ly impact the environment, workers' safety, and health. These adverse impacts led academia and industry toward devel-oping greener and sustainable amide forming synthetic routes to avoid, reduce or replace the use of these hazardous sol-vents. The present perspective fits into this framework and discusses the recent development of amide/peptide bond formations in water.

Item Type: Article
Date Deposited: 14 Jun 2022 00:45
Last Modified: 14 Jun 2022 00:45