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Crystal structure of 2-PG bound to BPGM

Clark, Kirk, Kulathila, Raviraj, Wright, Kirk, Isome, Yuko, Sage, David, Yang, Yi and Christodoulou, Constantina (2022) Crystal structure of 2-PG bound to BPGM. RCSB Protein Data Bank.


Red blood cells contain the enzyme, 2,3, Bisphophateglycerate mutase, BPGM. This enzyme carries out 3 catalytic reactions. The phosphatase reaction degrades 2,3-phosphoglyderate forming 3-phosphoglyderate and inorganic phosphate. For decades, 2-phosphoglyceric has been known as an activator of this reaction; however, its mechanism of action has been unknown. The crystal structure of BPGM complexed with 2-PG reveals the mechanism of action of this activator.

Item Type: Article
Date Deposited: 10 May 2022 00:45
Last Modified: 10 May 2022 00:45


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