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Searching for signals of evolutionary selection in 168 genes related to immune function.

Walshmartin, Emily and Sabeti, Pardis and Hutcheson, Holli B and Fry, Ben and Schaffner, Stephen F and de Bakker, Paul I W and Varilly, Patrick and Palma, Alejandro and Roy, Jessica and Cooper, Richard and Winkler, Cheryl and Zeng, Yi and de The, Guy and Lander, Eric S and O'Brien, Stephen and Altshuler, David (2006) Searching for signals of evolutionary selection in 168 genes related to immune function. Human Genetics, 119 (1-2). pp. 92-102. ISSN 0340-6717

Abstract

Pathogens have played a substantial role in human evolution, with past infections shaping genetic variation at loci influencing immune function. We selected 168 genes known to be involved in the immune response, genotyped common single nucleotide polymorphisms across each gene in three population samples (CEPH Europeans from Utah, Han Chinese from Guangxi, and Yoruba Nigerians from Southwest Nigeria) and searched for evidence of selection based on four tests for non-neutral evolution: minor allele frequency (MAF), derived allele frequency (DAF), Fst versus heterozygosity and extended haplotype homozygosity (EHH). Six of the 168 genes show some evidence for non-neutral evolution in this initial screen, with two showing similar signals in independent data from the International HapMap Project. These analyses identify two loci involved in immune function that are candidates for having been subject to evolutionary selection, and highlight a number of analytical challenges in searching for selection in genome-wide polymorphism data.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 14 Dec 2009 13:59
Last Modified: 14 Dec 2009 13:59
URI: https://oak.novartis.com/id/eprint/463

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