de Esch, Iwan J P, Erlanson, Daniel A, Jahnke, Wolfgang, Johnson, Christopher N and Walsh, Louise (2022) Fragment-to-Lead Medicinal Chemistry Publications in 2020. Journal of medicinal chemistry, 65 (1). pp. 84-99. ISSN 1520-4804

Abstract

Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies that were published in 2020. Having systematically analyzed annual scientific outputs since 2015, we discuss trends and best practices in terms of fragment libraries, target proteins, screening technologies, hit-optimization strategies, and the properties of hit fragments and the leads resulting from them. As well as the tabulated Fragment-to-Lead (F2L) programs, our 2020 literature review identifies several trends and innovations that promise to further increase the success of FBDD. These include developing structurally novel screening fragments, improving fragment-screening technologies, using new computer-aided design and virtual screening approaches, and combining FBDD with other innovative drug-discovery technologies.

Item Type:	Article
Keywords:	Animals Chemistry, Pharmaceutical Drug Design Drug Discovery Humans Publications Small Molecule Libraries
Date Deposited:	18 May 2022 00:45
Last Modified:	18 May 2022 00:45
URI:	https://oak.novartis.com/id/eprint/45936