Seidel, Jonathan, Goebel, Mathias, Dos Reis Rodrigues, Rui Claudio, Kaup, Nora, Rapp, Johanna, Frauenschuh, Achim, Shultz, Joseph and Cui, Huanchun (2021) Continuous Capture scale down model comparison of a continuous and a discrete approach. Biotechnology and Bioengineering. pp. 1-7.

Abstract

In continuous pharmaceutical manufacturing, consisting of a perfused batch fermentation and integrated continuous downstream processing (DSP), the continuous capture is the linking unit operation. For the development of this unit operation, scale-down models (SDMs) are crucial, whereas discrete, non-continuous SDMs are preferred over continuous SDM due to their simplistic nature, reduced material consumption, and shorter operation time. The results presented in this study show the suitability of a discrete SDM approach, compared to a continuous SDM for a continuous protein A purification step.

Item Type:	Article
Keywords:	Continuous capture; Continuous manufacturing; Scale-down model; Protein A chromatography
Date Deposited:	13 Nov 2021 00:45
Last Modified:	13 Nov 2021 00:45
URI:	https://oak.novartis.com/id/eprint/45483