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Advances toward transformative therapies for tendon diseases.

Freedman, Benjamin R, Mooney, David J and Weber, Eckhard (2022) Advances toward transformative therapies for tendon diseases. Science translational medicine, 14 (661). eabl8814. ISSN 1946-6242


Approved therapies for tendon diseases have not yet changed the clinical practice of symptomatic pain treatment and physiotherapy. This review article summarizes advances in the development of novel drugs, biologic products, and biomaterial therapies for tendon diseases with perspectives for translation of integrated therapies. Shifting from targeting symptom relief toward disease modification and prevention of disease progression may open new avenues for therapies. Deep evidence-based clinical, cellular, and molecular characterization of the underlying pathology of tendon diseases, as well as therapeutic delivery optimization and establishment of multidiscipline interorganizational collaboration platforms, may accelerate the discovery and translation of transformative therapies for tendon diseases.

Item Type: Article
Date Deposited: 22 Sep 2022 00:45
Last Modified: 22 Sep 2022 00:45


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