Continuous Slurry Plug Flow Fe/ppm Pd Nanoparticle-Catalyzed Suzuki-Miyaura Couplings in Water Utilizing Novel Solids Handling Equipment
Plummer, Scott, Robinson, Richard, Smith, Marie, Chang, Jim, Lipschutz, Bruce, Wood, Alex and Gallou, Fabrice (2021) Continuous Slurry Plug Flow Fe/ppm Pd Nanoparticle-Catalyzed Suzuki-Miyaura Couplings in Water Utilizing Novel Solids Handling Equipment. Green Chemistry, 23 (19). pp. 7724-7730. ISSN 1463-92621463-9270
Abstract
Herein are reported initial efforts to develop a generally accessible flow process, applying a heterogenous nanocatalyst to aqueous micelle-enabled Suzuki-Miyaura coupling reactions. Also disclosed is a new engineering solution (i.e., a self-draining back pressure regulator), which, when applied, enabled 1.5 hours of continuous operation leading to the production of 20 grams of a pharmaceutical intermediate.
Item Type: | Article |
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Date Deposited: | 25 Feb 2022 00:45 |
Last Modified: | 25 Feb 2022 00:45 |
URI: | https://oak.novartis.com/id/eprint/45328 |