Chen, Xinhui, Cui, Xiaoming, Pognan, Nathalie, Quinlan, Michelle, Kapoor, Shruti, Rahmanzadeh, Gholamreza, Giovannini, Monica and Marbury, Thomas C (2021) Pharmacokinetics of capmatinib in participants with hepatic impairment: A phase 1, open-label, single-dose, parallel-group study. British journal of clinical pharmacology. ISSN 1365-2125

Abstract

Capmatinib, a mesenchymal-epithelial transition factor tyrosine kinase inhibitor, is metabolized by cytochrome P450 (CYP) 3A4 and aldehyde oxidase. In individuals with hepatic impairment, alterations in hepatobiliary excretion and metabolism could lead to higher capmatinib exposure. We compared the pharmacokinetics of a single oral dose of capmatinib 200 mg administered to participants with varying degrees of hepatic impairment vs. matched controls with normal hepatic function.

Item Type:	Article
Date Deposited:	15 Jul 2021 00:45
Last Modified:	15 Jul 2021 00:45
URI:	https://oak.novartis.com/id/eprint/45288