Gallou, Fabrice (2021) α-Arylation of (Hetero)aryl Ketones in Aqueous Surfactant Media. Green chemistry, 23. pp. 4858-4865.

Abstract

α-Arylation reactions can be performed in water, enabled by a designer surfactant,under mild conditions and in the absence
of organic co-solvents. A multitude of aryl and heteroaryl ketones are amenable to coupling with functionalized aryl halides.
Use of a lipophilic base that can gain entry to the micellar inner cores mediates enolization. In some cases, palladium loadings
as low as 2500 ppm (0.25 mol %) are sufficient for coupling in a completely recyclable medium, exemplifying chemistry in
water.

Item Type:	Article
Date Deposited:	28 Sep 2021 00:45
Last Modified:	28 Sep 2021 00:45
URI:	https://oak.novartis.com/id/eprint/44915