Gallou, Fabrice (2021) Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water. Chem Comm, 57. pp. 11847-11850.

Abstract

Bio-catalytic reactions involving ene-reductases (EREDs) can be aided by the presence of the surfactant TPGS-750-M, which form nanomicelles in water and act as a “reservoir” for both starting materials and importantly, resulting products, thereby minimizing enzymatic inhibition. These nanomicelles also function as nanoreactors in which chemo-catalysis occurs, thus enabling both reaction types to carried out in various combinations, and in tandem within the same reaction vessel. Transformations that illustrate the variety of sequences that are now possible, including use of EREDs, and that feature the
interchange of reagent- and enzyme-based processes in a 1-pot operation, are highlighted as representative examples of this
environmentally attractive approach to organic synthesis in water.

Item Type:	Article
Date Deposited:	07 Dec 2021 00:45
Last Modified:	07 Dec 2021 00:45
URI:	https://oak.novartis.com/id/eprint/44830