Kocsis, Bernat (2012) Differential role of NR2A and NR2B subunits in NMDA receptor antagonist-induced cortical gamma oscillations. Biological Psychiatry, 1 (17). pp. 987-995. ISSN 0006-3223

Abstract

NMDA-R antagonists elicit psychotic symptoms in human and schizophrenia-relevant signs in rodents, including a strong increase in cortical gamma activity. We show that this phenomenon primarily depends on a specific subtype of NMDA-Rs which contains the NR2A subunit whereas blockade of NR2B, C, or D subunit-containing receptors do not elicit such massive gamma oscillations. Both NR2A and NR2B-selective NMDA-R antagonists induce, however, long-lasting elevations of gamma power specifically during REM sleep.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
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Keywords:	NR2a, NR2b, NMDA receptors, gamma activation, schizophrenia
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Date Deposited:	13 Oct 2015 13:15
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/4474