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Important considerations related to permeability of peptides

Vorherr, Thomas (2021) Important considerations related to permeability of peptides. Chimia., 75 (6). pp. 522-524.


This review on intracellular delivery and oral bioavailability of peptides reflects a number of principal investigations at Novartis. Our studies were aiming at either to understand features enabling peptides to interfere with intracellular protein-protein interactions, or to achieve a more patient-friendly delivery by the oral route. In the light of these objectives, we have also spent some effort on assay development to come up with alternative methods for monitoring cellular peptide uptake. This summary of our insights is thought to help in the assessment and development of peptide therapeutics requiring membrane transition

Item Type: Article
Date Deposited: 10 Jul 2021 00:45
Last Modified: 10 Jul 2021 00:45


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