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Physio-chemical Characterization in Drug Discovery

Zhou, Liping and Wang, Jianling (2008) Physio-chemical Characterization in Drug Discovery. Physio-chemical Characterization in Drug Discovery, 4. pp. 12-18.


Abstract: It is recognized that drug candidates with drug-like
properties are more likely to make into market. Thus druglike
property assessment has been integrated into the current
drug discovery and development process. In the past decade,
investment in this aspect appears to have been paid off as the
attrition rate due to poor pharmacokinetics and bioavailability
decreased drastically. Physico-chemical properties are closely
related to drug absorption and their values are used in predicting
bioavailability and interpreting other in vitro and in vivo
findings. Different approaches have been developed to address
these properties at different stages in drug discovery, including
hit finding, lead finding and optimization, and nomination for
development candidates. In this review we summarize the usage,
advantages and limitations of the approaches for physicochemical
characterization towards successful drug discovery.

Item Type: Article
Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15


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